Inhibition of tumor growth by monoclonal anti-I-J antibodies

J. A. Drebin, C. Waltenbaugh, S. Schatten, B. Benacerraf, M. I. Greene

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

In this paper we have examined the effects of i.v. administered monoclonal anti-I-J antibodies on tumor growth in syngeneic and semi-syngeneic hosts. These antibodies inhibit tumor growth in mice bearing the appropriate I-J-encoded gene product on their lymphoid cells at nanogram dosages. The spleens of monoclonal anti-I-J-treated primary tumor-bearing mice do not contain transferable tumor-specific cells. These findings suggest that inhibition of suppressor cell function may be the mechanism by which anti-I-J antibodies inhibit tumor growth. We have also demonstrated that tumors growing in F 1 hybrid mice are inhibited by monoclonal anti-I-J antibodies reactive with either parental haplotype and that there is no evidence of synergy when both antibodies are administered simultaneously. This may indicate that I-J molecules are codominantly expressed on a critical component of the F 1 suppressor pathway.

Original languageEnglish (US)
Pages (from-to)506-509
Number of pages4
JournalJournal of Immunology
Volume130
Issue number1
StatePublished - 1983

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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