Inhibitory effect of ritanserin on the 5-hydroxytryptophan-mediated cortisol, ACTH and prolactin secretion in humans

Myung A. Lee, J. Frank Nash, Marianne Barnes, Herbert Y. Meltzer*

*Corresponding author for this work

Research output: Contribution to journalArticle

49 Scopus citations

Abstract

Oral administration of the serotonin (5-HT) precursor l-5-hydroxytryptophan (5-HTP), 200 mg, significantly increased plasma cortisol levels in man. l-5-HTP had no significant effect on the plasma prolactin levels. A borderline effect of 5-HTP on plasma ACTH levels was found. Pretreatment with the 5-HT2/5-HT1C antagonist ritanserin (5 mg, PO, b.i.d. for 2 days) significantly inhibited 5-HTP-induced cortisol secretion. Ritanserin had no effect on the basal plasma cortisol or prolactin levels. These data are suggestive that 5-HTP stimulates cortisol secretion in man via 5-HT2/5-HT1C receptor mechanisms.

Original languageEnglish (US)
Pages (from-to)258-264
Number of pages7
JournalPsychopharmacology
Volume103
Issue number2
DOIs
StatePublished - Feb 1991

Keywords

  • 5-HT/5-HT receptors
  • 5-Hydroxytryptophan
  • Cortisol
  • Prolactin
  • Ritanserin

ASJC Scopus subject areas

  • Pharmacology

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