Oral administration of the serotonin (5-HT) precursor l-5-hydroxytryptophan (5-HTP), 200 mg, significantly increased plasma cortisol levels in man. l-5-HTP had no significant effect on the plasma prolactin levels. A borderline effect of 5-HTP on plasma ACTH levels was found. Pretreatment with the 5-HT2/5-HT1C antagonist ritanserin (5 mg, PO, b.i.d. for 2 days) significantly inhibited 5-HTP-induced cortisol secretion. Ritanserin had no effect on the basal plasma cortisol or prolactin levels. These data are suggestive that 5-HTP stimulates cortisol secretion in man via 5-HT2/5-HT1C receptor mechanisms.
- 5-HT/5-HT receptors
ASJC Scopus subject areas