Inhibitory effects of nitric oxide on invasion of human cancer cells

Feng Wang, Ruixue Zhang, Tian Xia, Erin Hsu, Ying Cai, Zhennan Gu, Oliver Hankinson*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Hypoxia increased the ability of two human cancer cell lines, PC-3M and T24, to invade through Matrigel, while sodium nitroprusside (SNP), a nitric oxide (NO) donor, strongly inhibited this invasion, along with down-regulating HIF-1α. SNP also inhibited the function of mitochondria in PC-3M cells, and mitochondrion-specific inhibitors reduced the invasion of these cells. Furthermore, knocking down either Rieske iron-sulfur protein (Fe-S) of mitochondrial complex III or HIF-1β in these cells decreased their invasive potential. Our findings suggest that NO inhibits invasion of cancer cells via both inhibition of HIF-1, and impairment of mitochondria.

Original languageEnglish (US)
Pages (from-to)274-282
Number of pages9
JournalCancer Letters
Issue number2
StatePublished - Nov 18 2007


  • Hypoxia Inducible Factor 1 (HIF-1)
  • Invasion
  • Mitochondria
  • Nitric oxide (NO)
  • Sodium nitroprusside (SNP)

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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