Inhibitory effects of nitric oxide on invasion of human cancer cells

Feng Wang; Ruixue Zhang; Tian Xia; Erin Hsu; Ying Cai; Zhennan Gu; Oliver Hankinson

doi:10.1016/j.canlet.2007.08.001

Inhibitory effects of nitric oxide on invasion of human cancer cells

Feng Wang, Ruixue Zhang, Tian Xia, Erin Hsu, Ying Cai, Zhennan Gu, Oliver Hankinson^*

^*Corresponding author for this work

Orthopaedic Surgery

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Hypoxia increased the ability of two human cancer cell lines, PC-3M and T24, to invade through Matrigel, while sodium nitroprusside (SNP), a nitric oxide (NO) donor, strongly inhibited this invasion, along with down-regulating HIF-1α. SNP also inhibited the function of mitochondria in PC-3M cells, and mitochondrion-specific inhibitors reduced the invasion of these cells. Furthermore, knocking down either Rieske iron-sulfur protein (Fe-S) of mitochondrial complex III or HIF-1β in these cells decreased their invasive potential. Our findings suggest that NO inhibits invasion of cancer cells via both inhibition of HIF-1, and impairment of mitochondria.

Original language	English (US)
Pages (from-to)	274-282
Number of pages	9
Journal	Cancer Letters
Volume	257
Issue number	2
DOIs	https://doi.org/10.1016/j.canlet.2007.08.001
State	Published - Nov 18 2007

Keywords

Hypoxia Inducible Factor 1 (HIF-1)
Invasion
Mitochondria
Nitric oxide (NO)
Sodium nitroprusside (SNP)

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.canlet.2007.08.001

Cite this

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title = "Inhibitory effects of nitric oxide on invasion of human cancer cells",

abstract = "Hypoxia increased the ability of two human cancer cell lines, PC-3M and T24, to invade through Matrigel, while sodium nitroprusside (SNP), a nitric oxide (NO) donor, strongly inhibited this invasion, along with down-regulating HIF-1α. SNP also inhibited the function of mitochondria in PC-3M cells, and mitochondrion-specific inhibitors reduced the invasion of these cells. Furthermore, knocking down either Rieske iron-sulfur protein (Fe-S) of mitochondrial complex III or HIF-1β in these cells decreased their invasive potential. Our findings suggest that NO inhibits invasion of cancer cells via both inhibition of HIF-1, and impairment of mitochondria.",

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author = "Feng Wang and Ruixue Zhang and Tian Xia and Erin Hsu and Ying Cai and Zhennan Gu and Oliver Hankinson",

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doi = "10.1016/j.canlet.2007.08.001",

language = "English (US)",

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T1 - Inhibitory effects of nitric oxide on invasion of human cancer cells

AU - Wang, Feng

AU - Zhang, Ruixue

AU - Xia, Tian

AU - Hsu, Erin

AU - Cai, Ying

AU - Gu, Zhennan

AU - Hankinson, Oliver

PY - 2007/11/18

Y1 - 2007/11/18

N2 - Hypoxia increased the ability of two human cancer cell lines, PC-3M and T24, to invade through Matrigel, while sodium nitroprusside (SNP), a nitric oxide (NO) donor, strongly inhibited this invasion, along with down-regulating HIF-1α. SNP also inhibited the function of mitochondria in PC-3M cells, and mitochondrion-specific inhibitors reduced the invasion of these cells. Furthermore, knocking down either Rieske iron-sulfur protein (Fe-S) of mitochondrial complex III or HIF-1β in these cells decreased their invasive potential. Our findings suggest that NO inhibits invasion of cancer cells via both inhibition of HIF-1, and impairment of mitochondria.

AB - Hypoxia increased the ability of two human cancer cell lines, PC-3M and T24, to invade through Matrigel, while sodium nitroprusside (SNP), a nitric oxide (NO) donor, strongly inhibited this invasion, along with down-regulating HIF-1α. SNP also inhibited the function of mitochondria in PC-3M cells, and mitochondrion-specific inhibitors reduced the invasion of these cells. Furthermore, knocking down either Rieske iron-sulfur protein (Fe-S) of mitochondrial complex III or HIF-1β in these cells decreased their invasive potential. Our findings suggest that NO inhibits invasion of cancer cells via both inhibition of HIF-1, and impairment of mitochondria.

KW - Hypoxia Inducible Factor 1 (HIF-1)

KW - Invasion

KW - Mitochondria

KW - Nitric oxide (NO)

KW - Sodium nitroprusside (SNP)

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Inhibitory effects of nitric oxide on invasion of human cancer cells

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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