Inhospital and Post-discharge Changes in Renal Function after Transcatheter Aortic Valve Replacement

John E.A. Blair, Kent Brummel, Julie L. Friedman, Prashant Atri, Ranya N. Sweis, Hyde Russell, Mark J. Ricciardi, S. Chris Malaisrie, Charles J. Davidson, James D. Flaherty*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


The aim of this study was to determine the influence of inhospital and post-discharge worsening renal function (WRF) on prognosis after transcatheter aortic valve replacement (TAVR). Severe chronic kidney disease and inhospital WRF are both associated with poor outcomes after TAVR. There are no data available on post-discharge WRF and outcomes. This was a single-center study evaluating all TAVR from June 1, 2008, to June 31, 2014. WRF was defined as an increase in serum creatinine of ≥0.3 mg/dl. Inhospital WRF was measured from day 0 until discharge or day 7 if the hospitalization was >7 days. Post-discharge WRF was measured at 30 days after discharge. Descriptive statistics, Kaplan-Meier time-to-event analysis, and multivariate logistic regression were used. In a series of 208 patients who underwent TAVR, 204 with complete renal function data were used in the inhospital analysis and 168 who returned for the 30-day follow-up were used in the post-discharge analysis. Inhospital WRF was seen in 28%, whereas post-discharge WRF in 12%. Inhospital and post-discharge WRF were associated with lower rates of survival; however, after multivariate analysis, only post-discharge WRF remained a predictor of 1-year mortality (hazard ratio 1.18, p = 0.030 for every 1 mg/dl increase in serum creatinine). In conclusion, the rate of inhospital WRF is higher than the rate of post-discharge WRF after TAVR, and post-discharge WRF is more predictive of mortality than inhospital WRF.

Original languageEnglish (US)
Pages (from-to)633-639
Number of pages7
JournalAmerican Journal of Cardiology
Issue number4
StatePublished - Feb 15 2016

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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