Initial experience with dual-energy computed tomography-guided bone biopsies of bone lesions that are occult on monoenergetic CT

Michael C. Burke*, Ankur Garg, Jonathan M. Youngner, Swati D. Deshmukh, Imran M. Omar

*Corresponding author for this work

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Objective: Our purpose was to determine whether dual-energy CT (DECT), specifically the bone marrow setting of the virtual noncalcium (VNCa) algorithm, could be used to identify and accurately biopsy suspected bone malignancies that were visible on magnetic resonance imaging (MRI), nuclear bone scintigraphy, or positron-emission tomography/computed tomography (PET/CT), but occult on monoenergetic computed tomography (CT) by virtue of being either isodense or nearly isodense to surrounding normal bone. Materials and Methods: We present 4 cases in which DECT was used to detect various malignant bone lesions and was successfully used to direct percutaneous DECT-guided bone biopsies. Results: Two of the lesions were solid tumor metastases (breast and prostate carcinoma), whereas two others were hematological malignancies (leukemia and lymphoma). This technique enabled us to confidently and accurately direct the biopsy needle into the target lesion. Conclusion: The authors demonstrate that the DECT VNCa bone marrow algorithm may be helpful in identifying isodense bone lesions of various histologies and may be used to guide percutaneous bone biopsies. This technique may help to maximize diagnostic yield, minimize the number of passes into the region of concern, and prevent patients from undergoing repeat biopsy.

Original languageEnglish (US)
Pages (from-to)605-613
Number of pages9
JournalSkeletal Radiology
Volume48
Issue number4
DOIs
StatePublished - Apr 1 2019

Keywords

  • Bone biopsy
  • Dual-energy CT
  • Isodense bone lesion

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Initial experience with dual-energy computed tomography-guided bone biopsies of bone lesions that are occult on monoenergetic CT'. Together they form a unique fingerprint.

  • Cite this