Initial Management of Fever and Neutropenia: A Practical Approach

Jenna Rossoff*, Leena B. Mithal

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Fever in the setting of neutropenia is one of the most common complications of cancer treatment in children. Given the potential morbidity and mortality, these patients need urgent evaluation with a special focus on key areas of susceptibility, remembering that they may not show the typical signs or symptoms of an infection. Prompt recognition of sepsis is vital to ensure that appropriate management occurs in an expedited manner to prevent further deterioration. Rapid administration of broad-spectrum antibiotics is the cornerstone of management, along with fluid resuscitation and other supportive care measures based on the patient's clinical status. This article provides a practical approach to the emergency department management of fever and neutropenia in the pediatric patient.

Original languageEnglish (US)
Pages (from-to)145-152
Number of pages8
JournalClinical Pediatric Emergency Medicine
Issue number2
StatePublished - Jun 2018


  • cancer
  • children
  • fever
  • management
  • neutropenia
  • sepsis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Emergency Medicine


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