Abstract
Previous studies in this laboratory have demonstrated that 48 hr of fasting suppresses and 72 hr of sucrose feeding (a model of voluntary overfeeding) stimulates sympathetic nervous system activity in rats. The experiments described here were undertaken to establish whether these diet-induced changes in sympathetic activity occur in the early phases of a fast and whether they persist beyond a 3 day period of overfeeding. The results indicate that changes in cardiac norepinephrine turnover can be detected during the first 24 hr of fasting or overfeeding, and that the increase in cardiac norepinephrine turnover induced by sucrose overfeeding is sustained over 8 days of sucrose administration.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 143-146 |
| Number of pages | 4 |
| Journal | Metabolism |
| Volume | 31 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 1982 |
Funding
From the Charles A. Dana Research Institute and the Thorndike Laboratory, Department of Medicine, Harvard Medical School and Beth Israel Hospital, Boston, Massachusetts. Receivedfor publication April I, 1981. Supported in part by lJ.S.P.H.S Grants AM 20378, HL 24084. Dr. Rappaport is a NIH Special Fellow, F 32 AM 06252. Address reprint requests io Dr. Lewis Landsberg, Beth fsrael Hospital, 330 Brookline Avenue, Boston, Massachusetts 02215. 0 1982 by Grune & Stratton, Inc. 0026~495/82/3102/0007$01.00/0
ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism