Initiation, duration and dissipation of diet-induced changes in sympathetic nervous system activity in the rat

Elizabeth B. Rappaport, James B. Young, Lewis Landsberg*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Previous studies in this laboratory have demonstrated that 48 hr of fasting suppresses and 72 hr of sucrose feeding (a model of voluntary overfeeding) stimulates sympathetic nervous system activity in rats. The experiments described here were undertaken to establish whether these diet-induced changes in sympathetic activity occur in the early phases of a fast and whether they persist beyond a 3 day period of overfeeding. The results indicate that changes in cardiac norepinephrine turnover can be detected during the first 24 hr of fasting or overfeeding, and that the increase in cardiac norepinephrine turnover induced by sucrose overfeeding is sustained over 8 days of sucrose administration.

Original languageEnglish (US)
Pages (from-to)143-146
Number of pages4
JournalMetabolism
Volume31
Issue number2
DOIs
StatePublished - Feb 1982

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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