Injectable biodegradable elastomer to aid in healing of bone fractures

Juan Sanabria, Samantha Huddleston, Guillermo Antonio Ameer

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: In the United States every year, there are over 500,000 fractures of the lower extremities.1 With current treatments, 10%-20% of fractures fall into delayed or nonunion categories.2 For successful bone healing, a key challenge is sufficient mechanical stability of the injury, as well as eventual biodegradability of the mechanical support to reduce stress shielding.1,2 As such, a market has developed for biodegradable materials that can enhance bone healing to aid in short term stabilization and long-term recovery. A commercial product approved by the FDA to aid in bone defects and certain skeletal fractures is calcium phosphate cement CPC.3 However, CPC is limited in its clinical use for bone fractures due to its weak mechanical properties of brittleness, low impact resistance, and low tensile strength.3 A bone cement that may address these issues is a biodegradable elastomer called POC poly1,8-ocatanediol-co-citratre, which was developed in the Ameer lab and has different clinical applications due to its biodegradability, tissue biocompatibility, and mechanical strength.4 Specifically, a composite consisting of POC and bioceramic hydroxyapatite HA has shown to have desirable biodegradable properties and mechanical characteristics similar to the range of values reported for tissue fixation devices.5 Bending, compression, tensile, and sheer strength were measured, but the fractural strength provided by this POC-HA composite remains untested.5 This study proposes an experiment to test the fractural strength provided by different POC-HA composites using a 3-point flexural bending test, with the goal of finding the ideal HA composite for desired mechanical characteristics.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - Jan 1 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

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