Injectable, statin-based, body heat-activated tough biodegradable nanocomposites for bone regeneration

Samantha Huddleston, Chongwen Duan, Guillermo Ameer

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Orthopedic reconstructive surgery aims to stabilize fractures, replace or repair missing bones, and reattach soft tissue to bone to promote tissue regeneration at the site of injury. While currently used materials, such as poly(methyl methacrylate) (PMMA) or calcium phosphate-based cements offer effective mechanical properties, they have poor handling characteristics, are not conducive to bone regeneration, and are not degradable in the body.1,2 The objective of this study was to develop and characterize an injectable, shape conforming polymer-ceramic-statin composite that cured in the body to become a tough resorbable bone-like matrix. This material is based on the methacrylated antioxidant polymer poly(1,8-octamethylene citrate) (mPOC), which has been shown to form osteoinductive composites when mixed with ceramic micro and nanoparticles.3 We investigated the addition of statins as an osteogenic and angiogenic component for bone regeneration.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

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