Injury and repair of central cholinergic neurons

A. C. Cuello, L. Garofalo, D. Maysinger, E. P. Pioro, A. Ribeiro Da Silva

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

This chapter discusses the injury and repair of the central cholinergic neurons. Trophic responses to β- nerve growth factor (NGF) by centrally located cholinergic neurons are well substantiated for septal-hippocampal and basalis-cortical projections. From the cellular and subcellular analysis of NGFR immunoreactive sites, it can be assumed that those responses are receptor mediated. The sequence of events that follow this receptor-ligand interaction may include induction of specific genes and second messenger systems, which result in the translation and/or modification of specific proteins involved in trophic responses. The interaction of gangliosides with β-NGF over central cholinergic neurons could occur at any of those levels. The possibility that this interaction occurs at the level of the cell membrane is considered in the chapter. Exogenous gangliosides are known to be incorporated into the neural cell membranes and immobilized GM1 is capable of binding β-NGF with low affinity. Therefore, it is possible that gangliosides could provide additional binding sites for growth factors or modify the state of the growth factor receptor.

Original languageEnglish (US)
Pages (from-to)301-311
Number of pages11
JournalProgress in brain research
Volume84
Issue numberC
DOIs
StatePublished - Jan 1 1990

ASJC Scopus subject areas

  • General Neuroscience

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