Innate immune response induced by Theiler's murine encephalomyelitis virus infection

Byung S. Kim*, JoAnn P. Palma, Daeho Kwon, Alyson C. Fuller

*Corresponding author for this work

Research output: Contribution to journalReview article

25 Scopus citations

Abstract

Although the causative agents of human multiple sclerosis (MS) are not known, it is suspected that a viral infection may be associated with the initiation of the disease. Several viral disease models in mice have been studied to understand the pathogenesis of demeylination. In particular, Theiler's murine encephalomyelitis virus-induced demyelinating disease (TMEV-IDD) has been extensively studied as a relevant model. Various cytokines and chemokines are produced upon viral infection by different cell types, including antigen-presenting cells (APCs) such as macrophages; dendritic cells (DCs); and glial cells, such as astrocytes, microglia, and oligodendrocytes. The upregulation of the corresponding molecules are also found in MS and are likely to play an important role in the protection and/or pathogenesis of chronic inflammatory demyelinating disease. In this review, the type of cells and molecules, gene-activation mechanisms as well as their potential roles in protection and pathogenesis will be discussed.

Original languageEnglish (US)
Pages (from-to)1-12
Number of pages12
JournalImmunologic Research
Volume31
Issue number1
DOIs
StatePublished - 2005

Keywords

  • Chemokines
  • Cytokines
  • Demyelination
  • Signal transduction
  • Theiler's virus

ASJC Scopus subject areas

  • Immunology

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