Innate immunity and rheumatoid arthritis

Angelica Gierut, Harris Perlman, Richard M. Pope*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

74 Scopus citations

Abstract

Innate immunity, with macrophages playing a central role, is critically important in the pathogenesis of RA. Although environmental insults such as smoking have been implicated in the initiation of rheumatoid arthritis (RA) in patients who express the shared epitope, the understanding of the role of innate immunity in the pathogenesis of this disease is also expanding. As the understanding continues to expand, enticing targets for new therapeutic interventions continue to be identified. This article focuses on cells of myelomonocytic origin, their receptors, and factors that interact with them.

Original languageEnglish (US)
Pages (from-to)271-296
Number of pages26
JournalRheumatic Disease Clinics of North America
Volume36
Issue number2
DOIs
StatePublished - May 2010

Keywords

  • Fibroblast
  • Macrophage
  • Receptor

ASJC Scopus subject areas

  • Rheumatology

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