Innovation and implementation determinants of HIV testing and linkage-to-care in the U.S. a systematic review

Alithia Zamantakis, James L. Merle, Artur A.F.L.N. Queiroz, Juan Pablo Zapata, Jasmine Deskins, Ana Michaela Pachicano, Melissa Mongrella, Dennis Henyee Li, Nanette Benbow, Carlos Gallo, Justin Dean Smith, Brian Stanley Mustanski*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Objective: To identify innovation and implementation determinants of HIV testing, diagnosis, and linkage-to-care in the U.S. Data sources and study setting: Between November 2020 and January 2022, a broad search strategy was employed in three literature databases: Ovid MEDLINE, PsycINFO, and Web of Science. Study design: A systematic review guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement. Data collection/extraction methods: A team of master’s and Ph.D.-level researchers screened eligible studies against the inclusion criteria and extracted the data using COVIDENCE software in pairs with consensus performed by a senior member of the team. Barriers and facilitators were extracted and analyzed according to the Consolidated Framework for Implementation Research (CFIR). Frequency of determinants across studies was mapped according to CFIR, valence, study design, delivery setting, unit of analysis, population of interest, region of the U.S., and year. Results: We identified 1,739 implementation and innovation determinants from 186 articles. Most determinants were for HIV testing rather than linkage-to-care. Most determinants were identified in the inner setting and individuals domains of CFIR, with the fewest identified in the process and innovations domains. Determinants of providers were only slightly more frequently identified than determinants of recipients. However, determinants of organizations and systems were rarely identified. Conclusion: This review provides a synthesis of innovation and implementation determinants of HIV testing and linkage-to-care using the most-cited implementation science (IS) framework, CFIR. This synthesis enables the larger field of HIV science to utilize IS in efforts to end the HIV epidemic and positions IS to consider the application of IS frameworks to fields like HIV.

Original languageEnglish (US)
Article number111
JournalImplementation Science Communications
Volume5
Issue number1
DOIs
StatePublished - Dec 2024

Funding

This work was supported by a supplement grant to the Third Coast Center for AIDS Research, an NIH-funded center (P30 AI117943). Additionally, this work is supported by the National Institute of Health training postdoctoral slot to JLM (NLM; T15LM007124), the National Center for Advancing Translational Science to JLM (1 L30 TR004276-01), and the National Institute of Mental Health to az and JPZ (T32MH130325).

Keywords

  • CFIR
  • Determinants of implementation
  • HIV linkage to care
  • HIV testing
  • HIV/AIDS
  • Implementation science
  • Systematic review

ASJC Scopus subject areas

  • Health Policy
  • Health Informatics
  • Public Health, Environmental and Occupational Health

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