Inoperable Biliary Tract and Primary Liver Tumors: Palliative Treatment Options

Sophia K. McKinley; Akhil Chawla; Cristina R. Ferrone

doi:10.1016/j.soc.2019.06.009

Inoperable Biliary Tract and Primary Liver Tumors: Palliative Treatment Options

Sophia K. McKinley, Akhil Chawla, Cristina R. Ferrone^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

Primary liver tumors are most commonly hepatocellular carcinoma and intrahepatic cholangiocarcinoma. Although surgical resection offers a chance for cure, these tumors generally present at a late, inoperable stage, necessitating an understanding of noncurative and palliative treatment options. These options include ablative therapies, including radiofrequency ablation; intra-arterial therapies, including transcatheter chemoembolization; biliary decompression; radiotherapy; systemic therapies, including traditional chemotherapeutic agents; and molecular therapies, such as sorafenib. Selection of nonoperative treatment depends on patient and tumor factors as well as institutional resources and expertise.

Original language	English (US)
Pages (from-to)	745-762
Number of pages	18
Journal	Surgical Oncology Clinics of North America
Volume	28
Issue number	4
DOIs	https://doi.org/10.1016/j.soc.2019.06.009
State	Published - Oct 2019
Externally published	Yes

Keywords

Ablative therapy
Chemoembolization
Cholangiocarcinoma
Hepatocellular carcinoma
Palliation
Targeted therapies

ASJC Scopus subject areas

Surgery
Oncology

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title = "Inoperable Biliary Tract and Primary Liver Tumors: Palliative Treatment Options",

abstract = "Primary liver tumors are most commonly hepatocellular carcinoma and intrahepatic cholangiocarcinoma. Although surgical resection offers a chance for cure, these tumors generally present at a late, inoperable stage, necessitating an understanding of noncurative and palliative treatment options. These options include ablative therapies, including radiofrequency ablation; intra-arterial therapies, including transcatheter chemoembolization; biliary decompression; radiotherapy; systemic therapies, including traditional chemotherapeutic agents; and molecular therapies, such as sorafenib. Selection of nonoperative treatment depends on patient and tumor factors as well as institutional resources and expertise.",

keywords = "Ablative therapy, Chemoembolization, Cholangiocarcinoma, Hepatocellular carcinoma, Palliation, Targeted therapies",

author = "McKinley, {Sophia K.} and Akhil Chawla and Ferrone, {Cristina R.}",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = oct,

doi = "10.1016/j.soc.2019.06.009",

language = "English (US)",

volume = "28",

pages = "745--762",

journal = "Surgical Oncology Clinics of North America",

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number = "4",

}

TY - JOUR

T1 - Inoperable Biliary Tract and Primary Liver Tumors

T2 - Palliative Treatment Options

AU - McKinley, Sophia K.

AU - Chawla, Akhil

AU - Ferrone, Cristina R.

PY - 2019/10

Y1 - 2019/10

N2 - Primary liver tumors are most commonly hepatocellular carcinoma and intrahepatic cholangiocarcinoma. Although surgical resection offers a chance for cure, these tumors generally present at a late, inoperable stage, necessitating an understanding of noncurative and palliative treatment options. These options include ablative therapies, including radiofrequency ablation; intra-arterial therapies, including transcatheter chemoembolization; biliary decompression; radiotherapy; systemic therapies, including traditional chemotherapeutic agents; and molecular therapies, such as sorafenib. Selection of nonoperative treatment depends on patient and tumor factors as well as institutional resources and expertise.

AB - Primary liver tumors are most commonly hepatocellular carcinoma and intrahepatic cholangiocarcinoma. Although surgical resection offers a chance for cure, these tumors generally present at a late, inoperable stage, necessitating an understanding of noncurative and palliative treatment options. These options include ablative therapies, including radiofrequency ablation; intra-arterial therapies, including transcatheter chemoembolization; biliary decompression; radiotherapy; systemic therapies, including traditional chemotherapeutic agents; and molecular therapies, such as sorafenib. Selection of nonoperative treatment depends on patient and tumor factors as well as institutional resources and expertise.

KW - Ablative therapy

KW - Chemoembolization

KW - Cholangiocarcinoma

KW - Hepatocellular carcinoma

KW - Palliation

KW - Targeted therapies

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U2 - 10.1016/j.soc.2019.06.009

DO - 10.1016/j.soc.2019.06.009

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EP - 762

JO - Surgical Oncology Clinics of North America

JF - Surgical Oncology Clinics of North America

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ER -

Inoperable Biliary Tract and Primary Liver Tumors: Palliative Treatment Options

Abstract

Keywords

ASJC Scopus subject areas

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