Insights into morphogenesis from a simple developmental system

Rex L Chisholm*, Richard A. Firtel

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

131 Scopus citations


We are only starting to understand the molecular mechanisms that underlie cell and tissue movements during morphogenesis in metazoans. Dictyostelium discoideum provides a valuable model system for understanding these events - as it has for chemotaxis - despite the many differences that exist between this social amoeba and more complex organisms. Genetic and genomic studies, combined with real-time imaging, have identified key pathways that regulate morphogenesis in D. discoideum, and which are likely to have similar roles in metazoans.

Original languageEnglish (US)
Pages (from-to)531-541
Number of pages11
JournalNature Reviews Molecular Cell Biology
Issue number7
StatePublished - Jul 1 2004

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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