Instability of Red Cell Shape Associated with the Absence of Membrane Glycophorin C

Candace A. Kuczmarski*, Armando R. Orlina, Lauri K. Delahanty, Edward R. Kuczmarski

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Abstract. Erythocytes from 3 Gerbich‐negative siblings readily converted to echinocytes when subjected to changing concentrations of sodium or lithium chloride. When erythrocyte membrane proteins were assayed by immunoblotting with human anti‐Ge 1,2, normal membranes were found to contain a reactive component of an approximate molecular weight of 33,000 daltons which was absent from the Gerbich‐negative individuals. PAS staining and mobility on SDS gels identified this component as glycophorin C. These observations indicate that glyocophorin C (β‐sialoglycoprotein) is a component of the Gerbich antigen and is involved in normal cell shape maintenance.

Original languageEnglish (US)
Pages (from-to)36-42
Number of pages7
JournalVox Sanguinis
Volume52
Issue number1-2
DOIs
StatePublished - Mar 1987

ASJC Scopus subject areas

  • Hematology

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