Personal response systems (PRS) are beneficial because they can facilitate instruction that implements the theoretical framework of How People Learn (HPL), which emphasizes learner-, knowledge-, community-, and assessment-centered approaches. In this work we present case studies of moderately large biomedical engineering and biology courses. We discuss what types of questions and classroom strategies are effective in supporting HPL-inspired induction. A possibly unrecognized benefit of using a PRS system is its effect on instructors. We discuss the beneficial effects of PRS use on instructors and the changes in teaching strategies these systems brought about. The insight about the fragility of students' knowledge revealed by the PRS prompted the instructors to invest more time in designing formative assessment and in developing ways to address misconceptions. Use of the PRS also prompted the instructors to expand their instruction from merely content to include thought processes typical in their domain. Finally, the community of learners that was generated or reinforced by PRS had a positive effect on encouraging classroom discussion, and the instructors' teaching evolved to take advantage of that.