Insulin and Hypertension: Lessons from Obesity

L. Landsberg*

*Corresponding author for this work

Research output: Contribution to journalEditorialpeer-review

34 Scopus citations

Abstract

Hyperinsulinemia is a well-recognized if incompletely understood concomitant of obesity. Diminished sensitivity to the effects of insulin on glucose uptake and metabolism in skeletal muscle, commonly referred to as “insulin resistance,” is known to contribute to the hyperinsulinemia of obesity by evoking an increase in pancreatic insulin secretion in order to maintain euglycemia. Decreased hepatic extraction of insulin in obese persons appears to be involved as well, as a consequence of increased levels of free fatty acids in the portal blood.1 A primary increase in insulin secretion mediated by the pancreatic nerves, and a secondary increase in response to excessive.

Original languageEnglish (US)
Pages (from-to)378-379
Number of pages2
JournalNew England Journal of Medicine
Volume317
Issue number6
DOIs
StatePublished - Aug 6 1987

ASJC Scopus subject areas

  • Medicine(all)

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