@article{9f7aef1874cf466585c5fb4d15cdccbd,
title = "Insulin hexamer dissociation dynamics revealed by photoinduced T-jumps and time-resolved X-ray solution scattering",
abstract = "The structural dynamics of insulin hexamer dissociation were studied by the photoinduced temperature jump technique and monitored by time-resolved X-ray scattering. The process of hexamer dissociation was found to involve several transient intermediates, including an expanded hexamer and an unstable tetramer. Our findings provide insights into the mechanisms of protien-protein association.",
author = "Dolev Rimmerman and Denis Leshchev and Hsu, {Darren J.} and Jiyun Hong and Baxter Abraham and Irina Kosheleva and Robert Henning and Chen, {Lin X.}",
note = "Funding Information: This work was supported by the National Institute of Health, under Contract No. R01-GM115761. B. A. acknowledges support from the U.S. Department of Energy (DOE), Office of Science Graduate Student Research program, administered by the Oak Ridge Institute for Science and Education, managed by ORAU under contract number DE-SC0014664, as well as from the U.S. DOE Office of Science, Office of Basic Energy Science, under award number DE-SC0016288. This research used resources of the APS, a U.S. DOE Office of Science User Facility operated for the DOE Office of Science by Argonne National Laboratory under Contract No. DE-AC02-06CH11357. Use of BioCARS was also supported by the National Institute of General Medical Sciences of the National Institutes of Health under grant number R24GM111072. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Time-resolved set-up at Sector 14 was funded in part through a collaboration with Philip Anfinrud (NIH/NIDDK). Optical equipment used for IR beam delivery at BioCARS was purchased with support from the Fraser lab at University of California San Francisco. We would also like to acknowledge Guy Macha (BioCARS) for his assistance in designing the sample holder. Portions of this work were performed at the DuPont-Northwestern-Dow Collaborative Access Team (DND-CAT) located at Sector 5 of the APS. DND-CAT is supported by Northwestern University, E.I. DuPont de Nemours & Co., and The Dow Chemical Company. Data was collected using an instrument funded by the National Science Foundation under Award Number 0960140. Publisher Copyright: {\textcopyright} 2018 The Royal Society of Chemistry and Owner Societies.",
year = "2018",
doi = "10.1039/c8pp00034d",
language = "English (US)",
volume = "17",
pages = "874--882",
journal = "Photochemical and Photobiological Sciences",
issn = "1474-905X",
publisher = "Royal Society of Chemistry",
number = "7",
}