Insulin hexamer dissociation dynamics revealed by photoinduced T-jumps and time-resolved X-ray solution scattering

Dolev Rimmerman, Denis Leshchev, Darren J. Hsu, Jiyun Hong, Baxter Abraham, Irina Kosheleva, Robert Henning, Lin X. Chen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

The structural dynamics of insulin hexamer dissociation were studied by the photoinduced temperature jump technique and monitored by time-resolved X-ray scattering. The process of hexamer dissociation was found to involve several transient intermediates, including an expanded hexamer and an unstable tetramer. Our findings provide insights into the mechanisms of protien-protein association.

Original languageEnglish (US)
Pages (from-to)874-882
Number of pages9
JournalPhotochemical and Photobiological Sciences
Volume17
Issue number7
DOIs
StatePublished - 2018

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry

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