Insulin resistance in women with polycystic ovary syndrome

Andrea Dunaif*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

64 Scopus citations


Polycystic ovary syndrome (PCOS) is associated with insulin resistance. There are also defects in pancreatic β-cell function in affected women. These abnormalities are heritable. There are post-binding defects in insulin receptor signaling, with selective resistance to insulin's metabolic actions and constitutively activated mitogenic signaling in skeletal muscle. Intrinsic and environmental abnormalities interact to produce peripheral insulin resistance in PCOS. A susceptibility gene region for PCOS is located on chromosome 19p13.2. The susceptibility allele is also associated with a metabolic phenotype.

Original languageEnglish (US)
Pages (from-to)S13-S14
JournalFertility and Sterility
Issue numberSUPPL. 1
StatePublished - Jul 2006


  • Polycystic ovary syndrome
  • androgens
  • insulin resistance
  • metabolic disorders

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine


Dive into the research topics of 'Insulin resistance in women with polycystic ovary syndrome'. Together they form a unique fingerprint.

Cite this