Intake of dietary carbohydrates in early adulthood and adolescence and breast density among young women

Seungyoun Jung, Olga Goloubeva, Nola Hylton, Catherine Klifa, Erin LeBlanc, John Shepherd, Linda Snetselaar, Linda Van Horn, Joanne F. Dorgan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Purpose: Carbohydrate intake increases postprandial insulin secretion and may affect breast density, a strong risk factor for breast cancer, early in life. We examined associations of adolescent and early adulthood intakes of total carbohydrates, glycemic index/load, fiber, and simple sugars with breast density among 182 young women. Methods: Diet was assessed using three 24-h recalls at each of five Dietary Intervention Study in Children (DISC) clinic visits when participants were age 10–19 years and at the DISC06 Follow-Up Study clinic visit when participants were age 25–29 years. Associations between energy-adjusted carbohydrates and MRI-measured percent dense breast volume (%DBV) and absolute dense breast volume (ADBV) at 25–29 years were quantified using multivariable-adjusted mixed-effects linear models. Results: Adolescent sucrose intakes and premenarcheal total carbohydrates intakes were modestly associated with higher %DBV (mean %DBVQ1 vs Q4, 16.6 vs 23.5% for sucrose; and 17.2 vs 22.3% for premenarcheal total carbohydrates, all Ptrend ≤ 0.02), but not with ADBV. However, adolescent intakes of fiber and fructose were not associated with %DBV and ADBV. Early adulthood intakes of total carbohydrates, glycemic index/load, fiber, and simple sugars were not associated with %DBV and ADBV. Conclusions: Insulinemic carbohydrate diet during puberty may be associated with adulthood breast density, but our findings need replication in larger studies. Clinical Trials Registration ClinicalTrials.gov Identifier, NCT00458588 April 9, 2007; NCT00000459 October 27, 1999.

Original languageEnglish (US)
Pages (from-to)631-642
Number of pages12
JournalCancer Causes and Control
Volume29
Issue number7
DOIs
StatePublished - Jul 1 2018

Keywords

  • Absolute dense breast volume
  • Absolute non-dense breast volume
  • Breast cancer
  • Breast density
  • Carbohydrate
  • Fiber
  • Fructose
  • Glycemic index
  • Glycemic load
  • Sucrose
  • Timing of exposure
  • Young women

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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