Integral calculus problem solving: An fMRI investigation

Frank Krueger, Maria Vittoria Spampinato, Matteo Pardini, Sinisa Pajevic, Jacqueline N. Wood, George H. Weiss, Steffen Landgraf, Jordan Grafman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Only a subset of adults acquires specific advanced mathematical skills, such as integral calculus. The representation of more sophisticated mathematical concepts probably evolved from basic number systems; however its neuroanatomical basis is still unknown. Using fMRI, we investigated the neural basis of integral calculus while healthy participants were engaged in an integration verification task. Solving integrals activated a left-lateralized cortical network including the horizontal intraparietal sulcus, posterior superior parietal lobe, posterior cingulate gyrus, and dorsolateral prefrontal cortex. Our results indicate that solving of more abstract and sophisticated mathematical facts, such as calculus integrals, elicits a pattern of brain activation similar to the cortical network engaged in basic numeric comparison, quantity manipulation, and arithmetic problem solving.

Original languageEnglish (US)
Pages (from-to)1095-1099
Number of pages5
Issue number11
StatePublished - Jul 16 2008


  • Arithmetic
  • Dorsolateral prefrontal cortex
  • Intraparietal sulcus
  • Mathematics
  • Superior parietal lobe

ASJC Scopus subject areas

  • Neuroscience(all)

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