Integrated, Transparent Silicon Carbide Electronics and Sensors for Radio Frequency Biomedical Therapy

Tuan Khoa Nguyen*, Sharda Yadav, Thanh An Truong, Mengdi Han, Matthew Barton, Michael Leitch, Pablo Guzman, Toan Dinh, Aditya Ashok, Hieu Vu, Van Dau, Daniel Haasmann, Lin Chen, Yoonseok Park, Thanh Nho Do, Yusuke Yamauchi, John A. Rogers, Nam Trung Nguyen, Hoang Phuong Phan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


The integration of micro- and nanoelectronics into or onto biomedical devices can facilitate advanced diagnostics and treatments of digestive disorders, cardiovascular diseases, and cancers. Recent developments in gastrointestinal endoscopy and balloon catheter technologies introduce promising paths for minimally invasive surgeries to treat these diseases. However, current therapeutic endoscopy systems fail to meet requirements in multifunctionality, biocompatibility, and safety, particularly when integrated with bioelectronic devices. Here, we report materials, device designs, and assembly schemes for transparent and stable cubic silicon carbide (3C-SiC)-based bioelectronic systems that facilitate tissue ablation, with the capability for integration onto the tips of endoscopes. The excellent optical transparency of SiC-on-glass (SoG) allows for direct observation of areas of interest, with superior electronic functionalities that enable multiple biological sensing and stimulation capabilities to assist in electrical-based ablation procedures. Experimental studies on phantom, vegetable, and animal tissues demonstrated relatively short treatment times and low electric field required for effective lesion removal using our SoG bioelectronic system. In vivo experiments on an animal model were conducted to explore the versatility of SoG electrodes for peripheral nerve stimulation, showing an exciting possibility for the therapy of neural disorders through electrical excitation. The multifunctional features of SoG integrated devices indicate their high potential for minimally invasive, cost-effective, and outcome-enhanced surgical tools, across a wide range of biomedical applications.

Original languageEnglish (US)
Pages (from-to)10890-10903
Number of pages14
JournalACS nano
Issue number7
StatePublished - Jul 26 2022


  • Bio-Integrated Electronics
  • Functional Endoscopy
  • Irreversible Electroporation
  • Radio Frequency Ablation
  • Silicon Carbide
  • Thermal Ablation

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)


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