Integration and Diagnostic Accuracy of 3T Nonendorectal coil Prostate Magnetic Resonance Imaging in the Context of Active Surveillance

Nicole E. Curci, Brian R. Lane, Prasad R. Shankar, Sabrina L. Noyes, Andrew K. Moriarty, Anthony Kubat, Chris Brede, Jeffrey S. Montgomery, Gregory B. Auffenberg, David C. Miller, James E. Montie, Arvin K. George, Matthew S. Davenport*

*Corresponding author for this work

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Objective: To evaluate the integration of 3T nonendorectal coil multiparametric prostate magnetic resonance imaging (mpMRI) at 2 high-volume practices that routinely use mpMRI in the setting of active surveillance. Materials and Methods: This was an institutional review board-approved, Health Insurance Portability and Accountability Act-compliant, and dual-institution retrospective cohort study. Subjects undergoing 3T mpMRI without endorectal coil at either study institution over a 13-month period (August 1, 2015-August 31, 2016) were selected based on predefined criteria: clinical T1/T2 Gleason 6 prostate cancer, prostate-specific antigen <15 ng/mL, ≥40 years old, mpMRI within 2 years of prostate biopsy, and Prostate Imaging Reporting and Data System (PI-RADS) v2 score assigned. Subjects surveilled for Gleason ≥3 + 4 prostate cancer were excluded. The primary outcome was detection of Gleason ≥3 + 4 prostate cancer on magnetic resonance-ultrasound fusion biopsy, standard biopsy, or prostatectomy within 6 months following mpMRI. Positive predictive values (PPVs) were calculated. Results: A total of 286 subjects (N = 193 from institution 1, N = 93 from institution 2) met the criteria. Most (87% [90 of 104]) with maximum PI-RADS v2 scores of 1-2 did not receive immediate biopsy or treatment and remained on active surveillance. Incidence and PPVs for PI-RADS v2 scores of ≥3 were the following: PI-RADS 3 (n = 57 [20%], PPV 21% [6 of 29]), PI-RADS 4 (n = 96 [34%], PPV 51% [39 of 77]), and PI-RADS 5 (n = 29 [13%], PPV 71% [20 of 28]). No Gleason ≥4 + 3 prostate cancer was identified for PI-RADS v2 scores of 1-3 (0 of 43 with histology). Following mpMRI and subsequent biopsy, 21% (61 of 286) of subjects were removed from active surveillance and underwent definitive therapy. Conclusion: The 3T nonendorectal coil mpMRI has been integrated into the care of patients on active surveillance and effectively stratifies risk of Gleason ≥3 + 4 prostate cancer in this population.

Original languageEnglish (US)
Pages (from-to)137-143
Number of pages7
JournalUrology
Volume116
DOIs
StatePublished - Jun 2018

ASJC Scopus subject areas

  • Urology

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    Curci, N. E., Lane, B. R., Shankar, P. R., Noyes, S. L., Moriarty, A. K., Kubat, A., Brede, C., Montgomery, J. S., Auffenberg, G. B., Miller, D. C., Montie, J. E., George, A. K., & Davenport, M. S. (2018). Integration and Diagnostic Accuracy of 3T Nonendorectal coil Prostate Magnetic Resonance Imaging in the Context of Active Surveillance. Urology, 116, 137-143. https://doi.org/10.1016/j.urology.2018.02.043