Integrative genome analysis of somatic p53 mutant osteosarcomas identifies Ets2-dependent regulation of small nucleolar RNAs by mutant p53 protein

INIS

• mutants 90%
• rna 50%
• osteosarcomas 50%
• mice 40%
• metastases 30%
• tumors 20%
• proteins 20%
• gain 20%
• genes 20%
• regulations 20%
• cancer 10%
• in vivo 10%
• humans 10%
• phenotype 10%
• comparative evaluations 10%
• enrichment 10%
• losses 10%
• mutations 10%
• inhibition 10%
• transcription factors 10%
• vulnerability 10%
• osteoblasts 10%

Biochemistry, Genetics and Molecular Biology

• P53 100%
• Mutant 70%
• Small Nucleolar RNA 40%
• Mouse Mutant 20%
• Protein P53 20%
• Development 10%
• down Regulation 10%
• Mutation 10%
• Mouse Model 10%
• Phenotype 10%
• Electric Potential 10%
• Transcription Factor 10%
• Binding Site 10%
• Knockout Mouse 10%
• RNA Gene 10%
• Regulatory Element 10%
• Transcriptome 10%
• RNA Sequence 10%
• Mutated Genes 10%
• Osteoblast 10%
• Drive 10%
• Regulatory Mechanism 10%