Integrins in human hepatocellular carcinoma tumorigenesis and therapy

Qiong Gao, Zhaolin Sun*, Deyu Fang*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Integrins are a family of transmembrane receptors that connect the extracellular matrix and actin skeleton, which mediate cell adhesion, migration, signal transduction, and gene transcription. As a bi-directional signaling molecule, integrins can modulate many aspects of tumorigenesis, including tumor growth, invasion, angiogenesis, metastasis, and therapeutic resistance. Therefore, integrins have a great potential as antitumor therapeutic targets. In this review, we summarize the recent reports of integrins in human hepatocellular carcinoma (HCC), focusing on the abnormal expression, activation, and signaling of integrins in cancer cells as well as their roles in other cells in the tumor microenvironment. We also discuss the regulation and functions of integrins in hepatitis B virus-related HCC. Finally, we update the clinical and preclinical studies of integrin-related drugs in the treatment of HCC.

Original languageEnglish (US)
Pages (from-to)253-268
Number of pages16
JournalChinese medical journal
Volume136
Issue number3
DOIs
StatePublished - Feb 5 2023

Keywords

  • Antitumor therapy
  • Hepatocellular carcinoma
  • Integrins

ASJC Scopus subject areas

  • General Medicine

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