Intense Focused Ultrasound Can Reliably Induce Sensations in Human Test Subjects in a Manner Correlated With the Density of Their Mechanoreceptors

Trevor C. Dickey, Rowen Tych, Michel Kliot, John D. Loeser, Kristin Pederson, Pierre D. Mourad*

*Corresponding author for this work

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

Sensations generated by intense focused ultrasound (iFU) can occur cutaneously and/or at depth, in contrast to other forms of stimulation (e.g., heat, electricity), whose action usually occurs only at the skin surface, or mechanical stimulation (e.g., von Frey hairs, calibrated forceps, tourniquets) that compress and thus stimulate all tissue. Previous work on iFU stimulation has led to the hypothesis that the tactile basis of iFU stimulation should correlate with the density of mechanoreceptors at the site of iFU stimulation. Here we tested that hypothesis, correlating a " two-point" neurological examination-a standard measure of superficial mechanoreceptor density-with the intensity of superficially applied iFU necessary to generate sensations with high sensitivity and specificity. We applied iFU at 1.1 MHz for 0.1 s to the fingertip pads of 17 test subjects in a blinded fashion and escalated intensities until they consistently observed iFU-induced sensations. Most test subjects achieved high values of sensitivity and specificity, doing so at values of spatially and temporally averaged intensity measuring <100 W/cm 2. Moreover, the test subjects' sensitivity to iFU stimulation correlated with the density of mechanoreceptors as determined by a standard two-point discrimination neurological examination, consistent with earlier hypotheses.

Original languageEnglish (US)
Pages (from-to)85-90
Number of pages6
JournalUltrasound in Medicine and Biology
Volume38
Issue number1
DOIs
StatePublished - Jan 1 2012

Keywords

  • Intense focused ultrasound
  • Mechanoreceptors
  • Sensation
  • Tactile sensitivity

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Biophysics
  • Acoustics and Ultrasonics

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