Intensification of bioactive compounds extraction from medicinal plants using ultrasonic irradiation

Renata Vardanega, Diego T. Santos*, M. A. De Almeida

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

67 Scopus citations


Extraction processes are largely used in many chemical, biotechnological and pharmaceutical industries for recovery of bioactive compounds from medicinal plants. To replace the conventional extraction techniques, new techniques as high-pressure extraction processes that use environment friendly solvents have been developed. However, these techniques, sometimes, are associated with low extraction rate. The ultrasound can be effectively used to improve the extraction rate by the increasing the mass transfer and possible rupture of cell wall due the formation of microcavities leading to higher product yields with reduced processing time and solvent consumption. This review presents a brief survey about the mechanism and aspects that affecting the ultrasound assisted extraction focusing on the use of ultrasound irradiation for high-pressure extraction processes intensification.

Original languageEnglish (US)
Pages (from-to)88-95
Number of pages8
JournalPharmacognosy Reviews
Issue number16
StatePublished - 2014


  • Bioactive compounds
  • extraction
  • high-pressure
  • process intensification
  • ultrasound

ASJC Scopus subject areas

  • Pharmacology
  • Plant Science
  • Drug Discovery
  • Complementary and alternative medicine


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