TY - JOUR
T1 - Intensive care unit patients with acquired immunodeficiency syndrome and Pneumocystis carinii pneumonia
T2 - Suggested predictors of hospital outcome
AU - Peruzzi, W. T.
AU - Skoutelis, A.
AU - Shapiro, B. A.
AU - Murphy, Robert Leo
AU - Currie, D. L.
AU - Cane, R. D.
AU - Noskin, Gary A
AU - Phair, John Phillip
PY - 1991/1/1
Y1 - 1991/1/1
N2 - Objective: To define our ICU experience with AIDS patients, Pneumocystis carinii pneumonia, and respiratory failure, and to delineate factors predictive of hospital survival. Design: A retrospective study in which logistic regression analysis was applied to data obtained during the first 144 hrs of ICU admission. Setting: A university hospital medical ICU associated with a national AIDS treatment center. Patients: Twenty-seven male patients with AIDS, P. carinii pneumonia, and respiratory failure who desired full supportive and resuscitative care. Measurements and Main Results: Of 27 patients who met study criteria, 19 (70%) were nonsurvivors and eight (30%) were survivors. The relative risk of death was 2.2 times greater in patients who exhibited the combination of pH <7.35 and a base deficit >4 mEq/L, at any time in their ICU course, than in patients who did not (95% confidence interval = 1.01, 4.81). Furthermore, the relative risk of death was 3.7 times greater in patients who required positive end-expiratory pressure >10 cm H2O after 96 hrs of ICU care than in those patients who did not (95% confidence interval = 1.09, 12.33). Indices of oxygen transfer, severity of chest radiograph abnormalities, concurrent lung infections, and most laboratory studies on hospital admission were not different between the two groups nor predictive of hospital survival. Conclusions: When dealing with AIDS/P. carinii pneumonia/ICU patients, it is not possible to distinguish who will survive to hospital discharge based on information routinely available before ICU admission. Those patients with the greatest chance of survival demonstrate a significant decrease in the required level of respiratory support within the first 4 days of ICU care. The presence of a metabolic acidemia (pH <7.35 and base deficit >4 mEq/L), at any time during the ICU course, is a poor prognostic sign. We suggest that such objective variables should be included in the development of any new outcome predictor model for this group of ICU patients.
AB - Objective: To define our ICU experience with AIDS patients, Pneumocystis carinii pneumonia, and respiratory failure, and to delineate factors predictive of hospital survival. Design: A retrospective study in which logistic regression analysis was applied to data obtained during the first 144 hrs of ICU admission. Setting: A university hospital medical ICU associated with a national AIDS treatment center. Patients: Twenty-seven male patients with AIDS, P. carinii pneumonia, and respiratory failure who desired full supportive and resuscitative care. Measurements and Main Results: Of 27 patients who met study criteria, 19 (70%) were nonsurvivors and eight (30%) were survivors. The relative risk of death was 2.2 times greater in patients who exhibited the combination of pH <7.35 and a base deficit >4 mEq/L, at any time in their ICU course, than in patients who did not (95% confidence interval = 1.01, 4.81). Furthermore, the relative risk of death was 3.7 times greater in patients who required positive end-expiratory pressure >10 cm H2O after 96 hrs of ICU care than in those patients who did not (95% confidence interval = 1.09, 12.33). Indices of oxygen transfer, severity of chest radiograph abnormalities, concurrent lung infections, and most laboratory studies on hospital admission were not different between the two groups nor predictive of hospital survival. Conclusions: When dealing with AIDS/P. carinii pneumonia/ICU patients, it is not possible to distinguish who will survive to hospital discharge based on information routinely available before ICU admission. Those patients with the greatest chance of survival demonstrate a significant decrease in the required level of respiratory support within the first 4 days of ICU care. The presence of a metabolic acidemia (pH <7.35 and base deficit >4 mEq/L), at any time during the ICU course, is a poor prognostic sign. We suggest that such objective variables should be included in the development of any new outcome predictor model for this group of ICU patients.
KW - Acid-base balance
KW - Acquired immunodeficiency syndrome
KW - Hemodynamics
KW - Intensive care unit
KW - Opportunistic infections
KW - Pneumocystis carinii pneumonia
KW - Positive end-expiratory pressure
KW - Prognosis
KW - Severity of illness index
KW - Survival
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U2 - 10.1097/00003246-199107000-00012
DO - 10.1097/00003246-199107000-00012
M3 - Article
C2 - 2055077
AN - SCOPUS:0025913152
SN - 0090-3493
VL - 19
SP - 892
EP - 900
JO - Critical Care Medicine
JF - Critical Care Medicine
IS - 7
ER -
