Intensive management of hepatic failure

Mary E. Rinella, Arun Sanyal*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


A substantial number of patients with liver failure are admitted to the intensive care unit; thus a thorough understanding of the prevention and treatment of complications in such patients is imperative. The management of liver failure is demanding and often involves the combined efforts of many specialists. Critically ill patients with hepatic failure encompass a broad spectrum of disease, ranging from acute liver failure in a patient with no prior history of liver disease, to acute on chronic liver failure. The initial assessment and management of acute liver failure are reviewed with an emphasis on the prevention and treatment of brain edema in the pretransplant setting. The current treatment of complications resulting from decompensated chronic liver disease such as portal hypertensive bleeding; infection, renal failure, and hepatic encephalopathy are then discussed.

Original languageEnglish (US)
Pages (from-to)241-261
Number of pages21
JournalSeminars in Respiratory and Critical Care Medicine
Issue number3
StatePublished - Jun 2006


  • Cerebral edema
  • Liver failure
  • Management
  • Portal hypertension

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Pulmonary and Respiratory Medicine


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