Intensive surveillance with biannual dynamic contrast-enhanced magnetic resonance imaging downstages breast cancer in BRCA1 mutation carriers

Rodrigo Santa Cruz Guindalini, Yonglan Zheng, Hiroyuki Abe, Kristen Whitaker, Toshio F. Yoshimatsu, Tom Walsh, David V Schacht, Kirti Kulkarni, Deepa Sheth, Marion S. Verp, Angela R. Bradbury, Jane Churpek, Elias Obeid, Jeffrey Mueller, Galina Khramtsova, Fang Liu, Akila Raoul, Hongyuan Cao, Iris L. Romero, Susan HongRobert Livingston, Nora Jaskowiak, Xiaoming Wang, Marcio Debiasi, Colin C. Pritchard, Mary Claire King, Gregory Karczmar, Gillian M. Newstead, Dezheng Huo, Olufunmilayo I. Olopade*

*Corresponding author for this work

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Purpose: To establish a cohort of high-risk women undergoing intensive surveillance for breast cancer. Experimental Design: We performed dynamic contrast-enhanced MRI every 6 months in conjunction with annual mammography (MG). Eligible participants had a cumulative lifetime breast cancer risk 20% and/or tested positive for a pathogenic mutation in a known breast cancer susceptibility gene. Results: Between 2004 and 2016, we prospectively enrolled 295 women, including 157 mutation carriers (75 BRCA1, 61 BRCA2); participants' mean age at entry was 43.3 years. Seventeen cancers were later diagnosed: 4 ductal carcinoma in situ (DCIS) and 13 early-stage invasive breast cancers. Fifteen cancers occurred in mutation carriers (11 BRCA1, 3 BRCA2, 1 CDH1). Median size of the invasive cancers was 0.61 cm. No patients had lymph node metastasis at time of diagnosis, and no interval invasive cancers occurred. The sensitivity of biannual MRI alone was 88.2% and annual MG plus biannual MRI was 94.1%. The cancer detection rate of biannual MRI alone was 0.7% per 100 screening episodes, which is similar to the cancer detection rate of 0.7% per 100 screening episodes for annual MG plus biannual MRI. The number of recalls and biopsies needed to detect one cancer by biannual MRI were 2.8 and 1.7 in BRCA1 carriers, 12.0 and 8.0 in BRCA2 carriers, and 11.7 and 5.0 in non-BRCA1/2 carriers, respectively. Conclusions: Biannual MRI performed well for early detection of invasive breast cancer in genomically stratified high-risk women. No benefit was associated with annual MG screening plus biannual MRI screening.

Original languageEnglish (US)
Pages (from-to)1786-1794
Number of pages9
JournalClinical Cancer Research
Volume25
Issue number6
DOIs
StatePublished - 2019

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Guindalini, R. S. C., Zheng, Y., Abe, H., Whitaker, K., Yoshimatsu, T. F., Walsh, T., Schacht, D. V., Kulkarni, K., Sheth, D., Verp, M. S., Bradbury, A. R., Churpek, J., Obeid, E., Mueller, J., Khramtsova, G., Liu, F., Raoul, A., Cao, H., Romero, I. L., ... Olopade, O. I. (2019). Intensive surveillance with biannual dynamic contrast-enhanced magnetic resonance imaging downstages breast cancer in BRCA1 mutation carriers. Clinical Cancer Research, 25(6), 1786-1794. https://doi.org/10.1158/1078-0432.CCR-18-0200