Inter-center variation in death or tracheostomy placement in infants with severe bronchopulmonary dysplasia

K. Murthy*, N. F.M. Porta, J. M. Lagatta, I. Zaniletti, W. E. Truog, T. R. Grover, L. D. Nelin, R. C. Savani

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

43 Scopus citations


Objective:To estimate the presence and sources of inter-center variation (ICV) in the risk of death or tracheostomy placement (D/T) among infants with severe bronchopulmonary dysplasia (sBPD)Study design:We analyzed the Children's Hospitals Neonatal Database between 2010 and 2013 to identify referred infants born <32 weeks' gestation with sBPD. The association between center and the primary outcome of D/T was analyzed by multivariable modeling. Hypothesized diagnoses/practices were included to determine if these explained any observed ICV in D/T.Results:D/T occurred in 280 (20%) of 1383 eligible infants from 21 centers. ICV was significant for D/T (range 2-46% by center, P<0.001) and tracheostomy placement (n=187, range 2-37%, P<0.001), but not death (n=93, range 0-19%, P=0.08). This association persisted in multivariable analysis (adjusted center-specific odds ratios for D/T varied 5.5-fold, P=0.009).Conclusions:ICV in D/T is apparent among infants with sBPD. These results highlight that the indications for tracheostomy (and subsequent chronic ventilation) remain uncertain.

Original languageEnglish (US)
Pages (from-to)723-727
Number of pages5
JournalJournal of Perinatology
Issue number6
StatePublished - Jun 1 2017

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Pediatrics, Perinatology, and Child Health


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