Inter-connection between mitochondria and HIFs

Kathryn V. Tormos, Navdeep S. Chandel*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

The transcription factors hypoxia inducible factors 1 and 2 (HIF-1 and HIF-2) regulate multiple responses to physiological hypoxia such as transcription of the hormone erythropoietin to enhance red blood cell proliferation, vascular endothelial growth factor to promote angiogenesis and glycolytic enzymes to increase glycolysis. Recent studies indicate that HIFs also regulate mitochondrial respiration and mitochondrial oxidative stress. Interestingly, mitochondrial metabolism, respiration and oxidative stress also regulate activation of HIFs. In this review, we examine the evidence that mitochondria and HIFs are intimately connected to regulate each other resulting in appropriate responses to hypoxia.

Original languageEnglish (US)
Pages (from-to)795-804
Number of pages10
JournalJournal of Cellular and Molecular Medicine
Volume14
Issue number4
DOIs
StatePublished - Apr 2010

Keywords

  • HIF
  • Mitochondria
  • ROS
  • Respiration

ASJC Scopus subject areas

  • Molecular Medicine
  • Cell Biology

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