Interaction between inhibitory and excitatory synaptic potentials at a peripheral neurone.

F. R. Edwards*, G. D. Hirst, E. M. Silinsky

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

1. The interaction between inhibitory and excitatory synaptic potentials in neurones lying in the submucous plexus of guinea‐pig ileum has been examined. 2. It was found that during an inhibitory conductance change, electrotonic potentials were more depressed in amplitude than were excitatory synaptic potentials. 3. It is suggested that inhibitory conductance changes may have only a slight effect on the impedance seen by excitatory synaptic currents as much of the excitatory synaptic current flow is likely to be capacitive. 4. A part of the depression of excitatory synaptic potential amplitude was not associated with changes in electrical properties of neurones and it is suggested that inhibitory transmitter may reduce the release of excitatory transmitter.

Original languageEnglish (US)
Pages (from-to)647-663
Number of pages17
JournalThe Journal of Physiology
Volume259
Issue number3
DOIs
StatePublished - Aug 1 1976

ASJC Scopus subject areas

  • Physiology

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