Interaction of human immunodeficiency virus type 1 and human herpesvirus type 8 infections on the incidence of Kaposi's sarcoma

Lisa P. Jacobson*, F. J. Jenkins, G. Springer, A. Muñoz, K. V. Shah, J. Phair, Z. F. Zhang, H. Armenian

*Corresponding author for this work

Research output: Contribution to journalArticle

97 Scopus citations

Abstract

To determine Kaposi's sarcoma (KS) risk related to timing of human immunodeficiency virus type 1 (HIV-1) and human herpesvirus type 8 (HHV-8) infections, stored longitudinal sera from 400 homosexual men with known dates of HIV-1 seroconversion (±4.5 months) were tested for HHV-8 antibody. Times from HHV-8 seroconversion to KS were compared for the 69 men who became infected with HHV-8 after acquiring HIV-1 to the 182 men who were HHV-8 seropositive before their HIV-1 infection. None developed KS before coinfection. HHV-8 seroconversion after HIV-1 infection increased the risk of KS (risk ratio, 2.55; 95% confidence interval, 1.06-6.10) compared with those infected with HHV-8 before HIV-1. The KS hazards in HHV-8-infected men increased by 60% (P < .001) for each year of HIV-1 infection. Faster CD4 cell loss and higher HIV-1 RNA levels significantly predicted KS. The quicker development of KS in men acquiring HHV-8 after HIV-1 and its association with CD4 slope argues that KS is more likely if HHV-8 infection occurs in an immunocompromised person.

Original languageEnglish (US)
Pages (from-to)1940-1949
Number of pages10
JournalJournal of Infectious Diseases
Volume181
Issue number6
DOIs
StatePublished - Jul 10 2000

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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    Jacobson, L. P., Jenkins, F. J., Springer, G., Muñoz, A., Shah, K. V., Phair, J., Zhang, Z. F., & Armenian, H. (2000). Interaction of human immunodeficiency virus type 1 and human herpesvirus type 8 infections on the incidence of Kaposi's sarcoma. Journal of Infectious Diseases, 181(6), 1940-1949. https://doi.org/10.1086/315503