Interaction of Vitamin E isoforms on asthma and allergic airway disease

Joan Cook-Mills*, Tebeb Gebretsadik, Hiam Abdala-Valencia, Jeremy Green, Emma K. Larkin, William D. Dupont, Xiao Ou Shu, Myron Gross, Chunxue Bai, Yu Tang Gao, Terryl J. Hartman, Christian Rosas-Salazar, Tina Hartert

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Prospective epidemiological studies, observational cross-sectional studies and some randomised prevention trials have demonstrated inconsistent findings of the impact of vitamin E on asthma risk. The goals of this study were to explore whether this differing association of vitamin E on asthma risk is due to an interaction of vitamin E isoforms. To address this question, in a population-based asthma incidence study we assessed the interaction between the plasma concentrations of vitamin E isoforms α-tocopherol and γ-tocopherol on asthma risk. Second, to understand the mechanisms of any interaction of these isoforms, we conducted experimental supplementation of α-tocopherol and γ-tocopherol isoforms in mice on the outcome of allergic airway inflammation. We found that in the highest γ-tocopherol tertile, low levels of α-tocopherol were associated with increased asthma risk, while highest tertile α-tocopherol levels trended to be protective. Similarly, in a mouse model of asthma, diet supplementation with α-tocopherol decreased lung inflammation in response to house dust mite (HDM) challenge. In contrast, diet supplementation with γ-tocopherol increased lung inflammation in response to HDM. These human and animal studies provide evidence for the competing effects of the vitamin E isoforms, in physiological concentrations, on asthma and allergic airway disease.

Original languageEnglish (US)
Pages (from-to)954-956
Number of pages3
JournalThorax
Volume71
Issue number10
DOIs
StatePublished - Oct 1 2016

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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