Interactions between Epac1 and ezrin in the control of endothelial barrier function

Euan Parnell, Stephen J. Yarwood*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

Loss of barrier function in the vasculature promotes inflammatory signalling which in turn contributes to the progression of cardiovascular disease. cAMP can protect against endothelial dysfunction through the effectors PKA (protein kinase A) and Epac (exchange protein directly activated by cAMP). The present review outlines the role of Epac1 signalling within the endothelium and, in particular, the role of Epac1 in cytoskeletal dynamics and the control of cell morphology. The actin/cytoskeleton linker ezrin will be described in terms of the growing body of evidence placing it downstream of cAMP signalling as a mediator of altered cellular morphology.

Original languageEnglish (US)
Pages (from-to)274-278
Number of pages5
JournalBiochemical Society transactions
Volume42
Issue number2
DOIs
StatePublished - Apr 2014
Externally publishedYes

Keywords

  • Cytoskeleton
  • Endothelium
  • Epac1
  • Ezrin
  • Rho
  • Spreading

ASJC Scopus subject areas

  • Biochemistry

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