Interactions Between Glycogen Synthase Kinase-3β Gene Polymorphisms, Negative Life Events, and Susceptibility to Major Depressive Disorder in a Chinese Population

Jiarun Yang, Siyuan Ke, Zhengxue Qiao, Xiuxian Yang, Xiaohui Qiu, Xuejia Song, Erying Zhao, Jiawei Zhou, Mingzhe Zhao, Yanjie Yang, Deyu Fang, Depin Cao*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Recent studies suggest that glycogen synthase kinase (GSK)-3β is involved in the development of major depressive disorder (MDD). The aim of this study was to investigate the interaction between GSK-3β polymorphism (rs6438552, rs334558, and rs2199503) and negative life events in the pathogenesis of major depressive disorder (MDD). Methods: DNA genotyping was performed on peripheral blood leukocytes in 550 patients with MDD and 552 age- and gender-matched controls. The frequency and severity of negative life events were assessed by the Life Events Scale (LES). A chi-square method was employed to assess the gene-environment interaction (G × E). Results: Differences in rs6438552, rs334558, and rs2199503 genotype distributions were observed between MDD patients and controls. Significant G × E interactions between allelic variation of rs6438552, rs334558, and rs2199503 and negative life events were observed. Individuals with negative life events and carrying genotypes of rs6438552 A+, rs334558 A+, and rs2199503G+ have increased the risk of depression. Conclusions: These results indicate that interactions between the GSK-3β rs6438552, rs334558, and rs2199503 polymorphisms and environment increases the risk of developing MDD.

Original languageEnglish (US)
Article number503477
JournalFrontiers in Psychiatry
Volume11
DOIs
StatePublished - Feb 15 2021

Keywords

  • gene-environment interaction
  • glycogen synthase kinase-3β
  • major depressive disorder
  • negative life events
  • polymorphism

ASJC Scopus subject areas

  • Psychiatry and Mental health

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