Interactions between segmented polyurethane surfaces and the plasma protein fibrinogen

S. I. Stupp*, J. W. Kauffman, S. H. Carr

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Surfaces of a segmented polyurethane were varied by casting on poly(ethylene terephthalate) (PET) and glass substrates, and were characterized through infrared‐attenuated total‐reflection spectroscopy (ATR). Surfaces cast on glass substrates showed a higher content of polyether segments, whereas those cast on PET contained a higher relative concentration of aromatic segments. Adsorption, and possible conformational changes of fibrinogen, were found to be more substantial on polymer surfaces having a higher content of polyether segments. It is concluded that the relatively good blood compatibility of segmented polyurethanes is partly due to the presence of peptide‐like bonds on aromatic segments.

Original languageEnglish (US)
Pages (from-to)237-250
Number of pages14
JournalJournal of Biomedical Materials Research
Issue number2
StatePublished - Mar 1977

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering


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