Intercellular junction assembly, dynamics, and homeostasis.

Kathleen J. Green*, Spiro Getsios, Sergey Troyanovsky, L. M. Godsel

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

183 Scopus citations

Abstract

Intercellular anchoring junctions are highly specialized regions of the plasma membrane where members of the cadherin family of transmembrane adhesion molecules on opposing cells interact through their extracellular domains, and through their cytoplasmic domains serve as a platform for organizing cytoskeletal anchors and remodelers. Here we focus on assembly of so-called "anchoring" or "adhering" junctions-adherens junctions (AJs) and desmosomes (DSMs), which associate with actin and intermediate filaments, respectively. We will examine how the assembly and function of AJs and DSMs are intimately connected during embryogenesis and in adult cells and tissues, and in some cases even form specialized "mixed" junctions. We will explore signaling and trafficking machineries that drive assembly and remodeling and how these mechanisms are co-opted in human disease.

Original languageEnglish (US)
Pages (from-to)a000125
JournalCold Spring Harbor Perspectives in Biology
Volume2
Issue number2
DOIs
StatePublished - Feb 2010

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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