Interconnected Clinical and Social Risk Factors in Breast Cancer and Heart Failure

Arjun Sinha; Avni Bavishi; Elizabeth A. Hibler; Eric H. Yang; Susmita Parashar; Tochukwu Okwuosa; Jeanne M. DeCara; Sherry Ann Brown; Avirup Guha; Diego Sadler; Sadiya S. Khan; Sanjiv J. Shah; Clyde W. Yancy; Nausheen Akhter

doi:10.3389/fcvm.2022.847975

Interconnected Clinical and Social Risk Factors in Breast Cancer and Heart Failure

Arjun Sinha, Avni Bavishi, Elizabeth A. Hibler, Eric H. Yang, Susmita Parashar, Tochukwu Okwuosa, Jeanne M. DeCara, Sherry Ann Brown, Avirup Guha, Diego Sadler, Sadiya S. Khan, Sanjiv J. Shah, Clyde W. Yancy, Nausheen Akhter^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

12 Scopus citations

Abstract

Breast cancer and heart failure share several known clinical cardiovascular risk factors, including age, obesity, glucose dysregulation, cholesterol dysregulation, hypertension, atrial fibrillation and inflammation. However, to fully comprehend the complex interplay between risk of breast cancer and heart failure, factors attributed to both biological and social determinants of health must be explored in risk-assessment. There are several social factors that impede implementation of prevention strategies and treatment for breast cancer and heart failure prevention, including socioeconomic status, neighborhood disadvantage, food insecurity, access to healthcare, and social isolation. A comprehensive approach to prevention of both breast cancer and heart failure must include assessment for both traditional clinical risk factors and social determinants of health in patients to address root causes of lifestyle and modifiable risk factors. In this review, we examine clinical and social determinants of health in breast cancer and heart failure that are necessary to consider in the design and implementation of effective prevention strategies that altogether reduce the risk of both chronic diseases.

Original language	English (US)
Article number	847975
Journal	Frontiers in Cardiovascular Medicine
Volume	9
DOIs	https://doi.org/10.3389/fcvm.2022.847975
State	Published - May 20 2022

Funding

SS has received research grants from the National Institutes of Health (U54 HL160273, R01 HL107577, R01 HL127028, R01 HL140731, and R01 HL149423), Actelion, AstraZeneca, Corvia, Novartis, and Pfizer; and has received personal fees from Abbott, Actelion, AstraZeneca, Amgen, Aria CV, Axon Therapies, Bayer, Boehringer-Ingelheim, Boston Scientific, Bristol-Myers Squibb, Cardiora, Coridea, CVRx, Cyclerion, Cytokinetics, Edwards Lifesciences, Eidos, Eisai, Imara, Impulse Dynamics, Intellia, Ionis, Ironwood, Lilly, Merck, MyoKardia, Novartis, Novo Nordisk, Pfizer, Prothena, Regeneron, Rivus, Sanofi, Shifamed, Tenax, Tenaya, and United Therapeutics. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Keywords

breast cancer
heart failure
reverse cardio-oncology
risk factors
social determinants of health

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3389/fcvm.2022.847975

Cite this

Sinha, A., Bavishi, A., Hibler, E. A., Yang, E. H., Parashar, S., Okwuosa, T., DeCara, J. M., Brown, S. A., Guha, A., Sadler, D., Khan, S. S., Shah, S. J., Yancy, C. W., & Akhter, N. (2022). Interconnected Clinical and Social Risk Factors in Breast Cancer and Heart Failure. Frontiers in Cardiovascular Medicine, 9, Article 847975. https://doi.org/10.3389/fcvm.2022.847975

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AB - Breast cancer and heart failure share several known clinical cardiovascular risk factors, including age, obesity, glucose dysregulation, cholesterol dysregulation, hypertension, atrial fibrillation and inflammation. However, to fully comprehend the complex interplay between risk of breast cancer and heart failure, factors attributed to both biological and social determinants of health must be explored in risk-assessment. There are several social factors that impede implementation of prevention strategies and treatment for breast cancer and heart failure prevention, including socioeconomic status, neighborhood disadvantage, food insecurity, access to healthcare, and social isolation. A comprehensive approach to prevention of both breast cancer and heart failure must include assessment for both traditional clinical risk factors and social determinants of health in patients to address root causes of lifestyle and modifiable risk factors. In this review, we examine clinical and social determinants of health in breast cancer and heart failure that are necessary to consider in the design and implementation of effective prevention strategies that altogether reduce the risk of both chronic diseases.

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Interconnected Clinical and Social Risk Factors in Breast Cancer and Heart Failure

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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