Intercorrelations among monoamine metabolite concentrations in human lumbar CSF are not due to a shared acid transport system

Michael Jibson, Kym F. Faull, John G. Csernansky*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Intercorrelations among homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA), and 3-methoxy-hydroxy-phenylglycol (MHPG) concentrations in lumbar cerebrospinal fluid (CSF) were examined before and after blockade of the acid transport system by probenecid in 59 psychiatric inpatients. The three compounds remained intercorrelated despite acid transport blockade, suggesting that the common transport system does not account for their covariance. Other possibilities to explain the interrelationship among these compounds are discussed.

Original languageEnglish (US)
Pages (from-to)595-602
Number of pages8
JournalBiological psychiatry
Volume28
Issue number7
DOIs
StatePublished - Oct 1 1990

ASJC Scopus subject areas

  • Biological Psychiatry

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