Interferon-α/β-receptor interactions: A complex story unfolding

Raj Deonarain, David C M Chan, Leonidas C. Platanias, Eleanor N. Fish*

*Corresponding author for this work

Research output: Contribution to journalReview article

40 Scopus citations

Abstract

The Type I interferons (IFN-α/β) exhibit pleiotropic biological activities. Notably, the different IFN subtypes activate the same cell surface receptor complex to mediate variable responses. Accumulating evidence suggests that distinct differences in critical amino acid residues among the different IFN-αs and IFN-β determine the nature of the ligand-receptor interaction and the subsequent responses. This review focuses on IFN-receptor interactions, the key residues involved in this interaction and the potential for targeted modifications of the ligand to enhance bioactivity.

Original languageEnglish (US)
Pages (from-to)2131-2137
Number of pages7
JournalCurrent Pharmaceutical Design
Volume8
Issue number24
DOIs
StatePublished - Oct 30 2002

Keywords

  • Binding residues
  • IFNAR1
  • IFNAR2
  • Interferon α/β

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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