Interferon α activates the tyrosine kinase Lyn in haemopoietic cells

Shahab Uddin, Isabella M. Grumbach, Taolin Yi, Oscar R. Colamonici, Leonidas C. Platanias*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

We investigated whether the src-family tyrosine kinase Lyn is involved in the generation of interferon α (IFNα) signals in haemopoietic cells. In vitro kinase assays using IFNα-sensitive cells of B-cell origin demonstrated the presence of IFNα-dependent kinase activity in anti-Lyn immunoprecipitates. Further studies demonstrated that Lyn associates via its src hemology 2 (SH2) domain with the Janus family tyrosine kinase Tyk-2. This interaction was IFNα-dependent and involved direct binding of the SH2 domain of Lyn to the IFNα-activated form of Tyk-2. Thus, during binding of IFNα to its receptor in malignant haemopoietic cells. Lyn is engaged in an IFNα- signalling pathway, probably downstream of Tyk-2.

Original languageEnglish (US)
Pages (from-to)446-449
Number of pages4
JournalBritish Journal of Haematology
Volume101
Issue number3
DOIs
StatePublished - 1998

Keywords

  • Interferon
  • Signal transduction
  • Tyrosine kinases

ASJC Scopus subject areas

  • Hematology

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