TY - JOUR
T1 - Interferon-α engages the insulin receptor substrate-1 to associate with the phosphatidylinositol 3′-kinase
AU - Uddin, Shahab
AU - Yenush, Lynne
AU - Sun, Xiao Jian
AU - Sweet, Michelle E.
AU - White, Morris F.
AU - Platanias, Leonidas C.
PY - 1995/7/7
Y1 - 1995/7/7
N2 - Interferon-α (IFNα) induces rapid tyrosine phosphorylation of the insulin receptor substrate-1 (IRS-1), a docking protein with multiple tyrosine phosphorylation sites that bind to the Src homology 2 (SH2) domains of various signaling proteins. During IFNα stimulation, the p85 regulatory subunit of the phosphatidylinositol 3′-kinase binds via its SH2 domains to tyrosine-phosphorylated IRS-1, and phosphatidylinositol 3′-kinase activity is detected in association with IRS-1. Thus, IFNα responses occur by activation of the IRS signaling system, which it shares with insulin, insulin-like growth factor-1, and interleukin-4.
AB - Interferon-α (IFNα) induces rapid tyrosine phosphorylation of the insulin receptor substrate-1 (IRS-1), a docking protein with multiple tyrosine phosphorylation sites that bind to the Src homology 2 (SH2) domains of various signaling proteins. During IFNα stimulation, the p85 regulatory subunit of the phosphatidylinositol 3′-kinase binds via its SH2 domains to tyrosine-phosphorylated IRS-1, and phosphatidylinositol 3′-kinase activity is detected in association with IRS-1. Thus, IFNα responses occur by activation of the IRS signaling system, which it shares with insulin, insulin-like growth factor-1, and interleukin-4.
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M3 - Article
C2 - 7608146
AN - SCOPUS:0028982917
SN - 0021-9258
VL - 270
SP - 15938
EP - 15941
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 27
ER -