Interferon β adenoviral gene therapy in a patient with ovarian cancer

Daniel H. Sterman; Colin T. Gillespie; Richard G. Carroll; Christina M. Coughlin; Elaina M. Lord; Jing Sun; Andrew Haas; Adri Recio; Larry R. Kaiser; George Coukos; Carl H. June; Steven M. Albelda; Robert H. Vonderheide

doi:10.1038/ncponc0658

Interferon β adenoviral gene therapy in a patient with ovarian cancer

Daniel H. Sterman, Colin T. Gillespie, Richard G. Carroll, Christina M. Coughlin, Elaina M. Lord, Jing Sun, Andrew Haas, Adri Recio, Larry R. Kaiser, George Coukos, Carl H. June, Steven M. Albelda, Robert H. Vonderheide^*

^*Corresponding author for this work

Medicine, Pulmonary Division

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Background: A 47-year-old woman with a history of ovarian cancer and a 6-year disease-free remission presented with dyspnea and increased abdominal girth. The patient was found to have ascites and a large left pleural effusion, both of which contained malignant cells consistent with recurrent ovarian cancer. Her disease progressed despite treatment with chemotherapeutic and hormonal agents. She was then enrolled in a phase I clinical trial of adenoviral-mediated interferon β gene therapy. Investigations: Abdominal and chest CT scans, 2-[¹⁸F]fluoro- 2-deoxyglucose PET scan, viral cultures, interferon cytokine analysis, immunophenotyping, and tumor cytotoxicity analyses. Diagnosis: Stage IV ovarian cancer with malignant ascites and pleural effusion. Management: Tunneled pleural catheter and intrapleural adenoviral-mediated interferon β gene therapy.

Original language	English (US)
Pages (from-to)	633-639
Number of pages	7
Journal	Nature Clinical Practice Oncology
Volume	3
Issue number	11
DOIs	https://doi.org/10.1038/ncponc0658
State	Published - Nov 2006

ASJC Scopus subject areas

Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Interferon β adenoviral gene therapy in a patient with ovarian cancer",

abstract = "Background: A 47-year-old woman with a history of ovarian cancer and a 6-year disease-free remission presented with dyspnea and increased abdominal girth. The patient was found to have ascites and a large left pleural effusion, both of which contained malignant cells consistent with recurrent ovarian cancer. Her disease progressed despite treatment with chemotherapeutic and hormonal agents. She was then enrolled in a phase I clinical trial of adenoviral-mediated interferon β gene therapy. Investigations: Abdominal and chest CT scans, 2-[18F]fluoro- 2-deoxyglucose PET scan, viral cultures, interferon cytokine analysis, immunophenotyping, and tumor cytotoxicity analyses. Diagnosis: Stage IV ovarian cancer with malignant ascites and pleural effusion. Management: Tunneled pleural catheter and intrapleural adenoviral-mediated interferon β gene therapy.",

author = "Sterman, {Daniel H.} and Gillespie, {Colin T.} and Carroll, {Richard G.} and Coughlin, {Christina M.} and Lord, {Elaina M.} and Jing Sun and Andrew Haas and Adri Recio and Kaiser, {Larry R.} and George Coukos and June, {Carl H.} and Albelda, {Steven M.} and Vonderheide, {Robert H.}",

year = "2006",

month = nov,

doi = "10.1038/ncponc0658",

language = "English (US)",

volume = "3",

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T1 - Interferon β adenoviral gene therapy in a patient with ovarian cancer

AU - Sterman, Daniel H.

AU - Gillespie, Colin T.

AU - Carroll, Richard G.

AU - Coughlin, Christina M.

AU - Lord, Elaina M.

AU - Sun, Jing

AU - Haas, Andrew

AU - Recio, Adri

AU - Kaiser, Larry R.

AU - Coukos, George

AU - June, Carl H.

AU - Albelda, Steven M.

AU - Vonderheide, Robert H.

PY - 2006/11

Y1 - 2006/11

N2 - Background: A 47-year-old woman with a history of ovarian cancer and a 6-year disease-free remission presented with dyspnea and increased abdominal girth. The patient was found to have ascites and a large left pleural effusion, both of which contained malignant cells consistent with recurrent ovarian cancer. Her disease progressed despite treatment with chemotherapeutic and hormonal agents. She was then enrolled in a phase I clinical trial of adenoviral-mediated interferon β gene therapy. Investigations: Abdominal and chest CT scans, 2-[18F]fluoro- 2-deoxyglucose PET scan, viral cultures, interferon cytokine analysis, immunophenotyping, and tumor cytotoxicity analyses. Diagnosis: Stage IV ovarian cancer with malignant ascites and pleural effusion. Management: Tunneled pleural catheter and intrapleural adenoviral-mediated interferon β gene therapy.

AB - Background: A 47-year-old woman with a history of ovarian cancer and a 6-year disease-free remission presented with dyspnea and increased abdominal girth. The patient was found to have ascites and a large left pleural effusion, both of which contained malignant cells consistent with recurrent ovarian cancer. Her disease progressed despite treatment with chemotherapeutic and hormonal agents. She was then enrolled in a phase I clinical trial of adenoviral-mediated interferon β gene therapy. Investigations: Abdominal and chest CT scans, 2-[18F]fluoro- 2-deoxyglucose PET scan, viral cultures, interferon cytokine analysis, immunophenotyping, and tumor cytotoxicity analyses. Diagnosis: Stage IV ovarian cancer with malignant ascites and pleural effusion. Management: Tunneled pleural catheter and intrapleural adenoviral-mediated interferon β gene therapy.

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Interferon β adenoviral gene therapy in a patient with ovarian cancer

Abstract

ASJC Scopus subject areas

UN SDGs

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