Interferon γ (IFNγ) signaling via mechanistic target of rapamycin complex 2 (mTORC2) and regulatory effects in the generation of type II interferon biological responses

Barbara Kroczynska, Robert L. Rafidi, Beata Majchrzak-Kita, Ewa M. Kosciuczuk, Gavin T. Blyth, Jacek Jemielity, Zofia Warminska, Diana Saleiro, Swarna Mehrotra, Ahmet Dirim Arslan, Eleanor N. Fish, Leonidas C. Platanias*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

We provide evidence for a unique pathway engaged by the type II IFN receptor, involving mTORC2/AKT-mediated downstream regulation of mTORC1 and effectors. These events are required for formation of the eukaryotic translation initiation factor 4F complex (eIF4F) and initiation ofmRNAtranslation of type II interferon-stimulated genes. Our studies establish that Rictor is essential for the generation of type II IFN-dependent antiviral and antiproliferative responses and that it controls the generation of type II IFN-suppressive effects on normal and malignant hematopoiesis. Together, our findings establish a central role for mTORC2 in IFNγ signaling and type II IFN responses.

Original languageEnglish (US)
Pages (from-to)2389-2396
Number of pages8
JournalJournal of Biological Chemistry
Volume291
Issue number5
DOIs
StatePublished - Jan 29 2016

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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