Interferon-γ-oligodendrocyte interactions in the regulation of experimental autoimmune encephalomyelitis

Roumen Balabanov, Krystle Strand, Rajendra Goswami, Eileen McMahon, Wendy Begolka, Stephen D. Miller, Brian Popko*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

111 Scopus citations


Experimental autoimmune encephalomyelitis (EAE) is an animal model of the human demyelinating disorder multiple sclerosis (MS). The immune cytokine interferon-gamma (IFN-γ) is believed to participate in disease pathogenesis in both EAE and MS. In the present study, we examined the significance of IFN-γ-oligodendrocyte interactions in the course of EAE. For the purpose of our study, we used the previously described [proteolipid protein/suppressor of cytokine signaling 1 (PLP/SOCS1)] transgenic mouse line that displays suppressed oligodendrocyte responsiveness to IFN-γ. PLP/SOCS1 mice developed EAE with an accelerated onset associated with enhanced early inflammation and markedly increased oligodendrocyte apoptosis. Moreover, we found that IFN-γ pretreatment of mature oligodendrocytes in vitro had a protective effect against oxidative stress and the inhibition of proteasome activity and resulted in upregulation in expression of a number of chemokines, including CXCL10 (IP10), CCL2 (MCP-1), CCL3 (MCP-1α), and CCL5 (RANTES). These results suggest that IFN-γ-oligodendrocyte interactions are of significance to the clinical and pathological aspects of EAE. In addition, the present study suggests that oligodendrocytes are not simply targets of inflammatory injury but active participants of the neuroimmune network operating during the course of EAE.

Original languageEnglish (US)
Pages (from-to)2013-2024
Number of pages12
JournalJournal of Neuroscience
Issue number8
StatePublished - Feb 21 2007


  • Cytokine
  • Demyelination
  • Inflammation
  • Multiple sclerosis
  • Oligodendrocytes
  • Transgenic

ASJC Scopus subject areas

  • Neuroscience(all)


Dive into the research topics of 'Interferon-γ-oligodendrocyte interactions in the regulation of experimental autoimmune encephalomyelitis'. Together they form a unique fingerprint.

Cite this