Interferon γ stabilizes the T helper cell type 1 phenotype

Yongkang Zhang, Ron Apilado, John Coleman, Shlomo Ben-Sasson, Sharon Tsang, Jane Hu-Li, William E. Paul, Hua Huang*

*Corresponding author for this work

Research output: Contribution to journalArticle

65 Scopus citations

Abstract

T helper cell (Th)1-primed CD4 T cells from wild-type donors make little interleukin (IL)-4 when restimulated under Th2 conditions. However, such restimulation of Th1-primed cells from interferon (IFN)-γ-/- or IFN-γ receptor (IFN-γR)-/- mice resulted in substantial production of IL-4 and other Th2 cytokines. Adding IFN-γ to the priming culture markedly diminished the capacity of Th1-primed IFN-γ-/- cells to express IL-4. Even IFN-γ-producing cells from IFN-γR-/- mice could acquire IL-4-producing capacity. Thus, IFN-γ is not required for the development of IFN-γ-producing capacity, but it plays a critical role in suppressing the IL-4-producing potential of Th1 cells.

Original languageEnglish (US)
Pages (from-to)165-172
Number of pages8
JournalJournal of Experimental Medicine
Volume194
Issue number2
DOIs
StatePublished - Jul 16 2001

Keywords

  • Cell cloning
  • Commitment
  • Differentiation
  • IL-12
  • IL-4

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Zhang, Y., Apilado, R., Coleman, J., Ben-Sasson, S., Tsang, S., Hu-Li, J., Paul, W. E., & Huang, H. (2001). Interferon γ stabilizes the T helper cell type 1 phenotype. Journal of Experimental Medicine, 194(2), 165-172. https://doi.org/10.1084/jem.194.2.165