Interferon alfa-2a for cryoglobulinemia associated with hepatitis C virus

V. Agnello, G. Knight, C. Abel, D. R. Ganger, D. M. Jensen, R. Misiani, F. Bellavita, O. Vicari

Research output: Contribution to journalLetterpeer-review

6 Scopus citations


To the Editor: Misiani and colleagues (March 17 issue)1 conclude that the therapeutic efficacy of interferon alfa-2a in cryoglobulinemia associated with hepatitis C virus (HCV) is closely related to the drug's antiviral activity. However, the authors do not present sufficient data to justify this conclusion. The demonstration that HCV is specifically concentrated in type II cryoglobulins suggests that the virus may be involved in the development of the disease and that the effect of interferon alfa may be due to its antiviral activity2; however, it has also been demonstrated that mixed cryoglobulins diminish immune-complex clearance mechanisms3. In view.

Original languageEnglish (US)
Pages (from-to)400-401
Number of pages2
JournalNew England Journal of Medicine
Issue number6
StatePublished - Aug 11 1994

ASJC Scopus subject areas

  • General Medicine


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